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Dr. Xue-Zhong Yu

Robert K. Stewart, MD, Distinguished Chair in Hematology/Oncology

Cancer Stem Cell Biology

  • Post-doc fellow, Fred Hutchinson Cancer Research Center and University of Washington Medical School
  • M.D. in Medicine and M.S. in Immunology, Beijing University Medical School
  • M.B.A. in the Citadel Graduate College
  • Leading expert in immunotherapy research, focused on hematopoietic stem cell transplantation as a therapy for hematologic malignancy
  • Research team has made significant contributions to our understanding of how T-cell activation and differentiation impact graft-versus-host (GVH) and graft-versus-leukemia (GVL) responses
  • Within the scope of immunotherapy, research extends to micro-RNA regulation, complement, metabolism and microbiota
  • Continuous and extensive NIH funding

Dr. Yu’s research focuses on the biology of graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) after allogeneic hematopoietic stem cell transplantation (HSCT). The ultimate goal of these studies is to prevent or treat GVHD while preserving the GVL effect, which could greatly enhance the therapeutic potential of HSCT.

Dr. Yu and his team have made significant contributions to understand how T-cell activation, metabolism, costimulation, and differentiation impact GVHD development and GVL activity.

A leading investigator in the research field of Hematopoietic Stem Cell Transplantation (HSCT), which is a curative option to treat hematologic malignancies.

Awarded NIH grants continuously since 2000.

Dr. Yu’s research is currently supported by three R01 and one R21 grants from the National Institute of Health.

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