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Molecular Proteomics in Cardiovascular Disease and Prevention

Center of Economic Excellence



Award Amount

$5 million

External Funding Above Match

$7.6 Million

Endowed Chair(s)

Dr. Sheldon E. Litwin

Dr. Thomas G. DiSalvo

Research Focus

Translation advances in basic bench scien to clinical bedside care to improve the health care of the citizens of South Carolina. Priorities include diagnostic techniques, therapeutic management strategies, relations of protein signatures to clinical outcomes for risk assessment, and treatment of disease manifestation.

University Partner

Medical University of South Carolina (MUSC)

Private Sector Partner

Health Sciences South Carolina

This Center advances cardiovascular prevention and treatment bench science into clinical bedside care. This Center’s goals include:

  • Developing measurement systems to detect early heart failure indicators.
  • Relating diagnostic protein signatures to clinical outcomes.
  • Developing therapeutic management strategies.
  • Creating a statewide network to develop, test, and improve clinical care of heart failure.
  • Transferring technology into new South Carolina industries.

The Center maintains a statewide network of five primary, separate care locations to participate and be linked by a central bioinformatics core. This core will allow patients who currently suffer or are at risk for cardiovascular disease from across the state to be screened. In 2009, plasma screening was conducted for 450 patients. Through this screening, 16 plasma proteins were analyzed and a specific biomarker portfolio was created for the diagnosis and prediction of left ventricular hypertrophy and diastolic heart failure.

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