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Dr. Mitzi Nagarkatti

SmartState Endowed Chair of Cancer Drug Discovery

Cancer Drug Discovery


  •   Drug discovery and mechanisms of inflammation in diseases such as colitis and colon cancer, multiple sclerosis, autoimmune hepatitis, obesity, lupus, and acute lung injury induced by Staphylococcal enterotoxins

  • Epigenetic mechanisms including dysregulation in microRNA expression, DNA methylation and histone modifications underlying immune dysfunction in autoimmune and inflammatory diseases as well as cancer

  • Regulation of microbiome and metabolome by botanicals such as indoles, resveratrol, cannabinoids and the like

  • Immunotoxicity induced by environmental pollutants and endocrine disruptors including dioxins and estrogens
  •  Immunopathogensis in post-traumatic stress disorder (PTSD), sepsis and endometriosis patients

Dr. Mitzi Nagarkatti is also Carolina Distinguished Professor and Chair of Department of Pathology, Microbiology and Immunology at the University of South Carolina (UofSC), School of Medicine at Columbia. Dr. Nagarkatti is an American Association for the Advancement of Sciences (AAAS) Fellow as well as a Fellow of the Academy of Toxicological Sciences. She has attracted >$50million in extramural funding as Principal Investigator (PI) or Co-PI since joining UofSC in 2005. Under Dr. Nagarkatti’s leadership, her department funding has grown significantly from ~$600K in 2004 to ~$9 million in 2018 and the departmental ranking also improved from 81st in 2004 to 25th in 2018 among Departments of Pathology at all US medical schools, based on NIH funding. Dr. Nagarkatti has trained several doctoral students, postdoctoral and clinical fellows, residents and junior faculty in her lab. She has published ~275 scientific papers and her research has received national and international patents, one of which was licensed to a company and has been approved by the FDA as an orphan drug to treat autoimmune hepatitis. Dr. Nagarkatti has served on numerous NIH Study Sections, American Cancer Society grant review panels, and on the Board of Scientific Counselors for the National Toxicology Program.

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